Global Shortage of Hepatitis A Vaccine and Dose Sparing Recommendations

*Update*  We now have stock of hepatitis A+B vaccine. 

Jun 2017 – Global Shortage of Hepatitis A Vaccine and Dose Sparing Recommendations

The current global shortage of hepatitis A vaccine is ongoing and continues to affect the supply of hepatitis A containing vaccines in the United Kingdom. Consequently it has become necessary to consider options for hepatitis A dose sparing as some products may be unavailable or may need to be prioritised for special risk groups. We are currently in stock for paediatric Hepatitis A.

The following temporary guidance is approved by the Joint Committee on Vaccination and Immunisation (JCVI) for health professionals in the UK:

  • Hepatitis A vaccine use should be prioritised for high risk travellers; a thorough risk assessment will help ensure vaccine recommendations are appropriate.
  • If an adult monovalent hepatitis A vaccine is not available immunocompetent adults can be given a single priming dose of either paediatric monovalent hepatitis A or adult combination hepatitis A/B vaccine (off-label).
  • Non hepatitis A immune HIV positive people should preferentially receive standard adult antigen content monovalent hepatitis A as a priming dose due to the poorer response rates to vaccine in this group.
  • If an adult monovalent hepatitis A vaccine is not available then adults that have been primed with adult monovalent hepatitis A can be given a booster dose of either paediatric monovalent hepatitis A or adult combination hepatitis A/B vaccine (off-label).
  • Adults that have been primed with adult monovalent hepatitis A can have their booster dose delayed beyond the recommended 12 months, to five years, in most circumstances.